Background: Bone diseases are common complications in HIV infected patients with increased fracture rates. Factors, calcium and Vitamin D deficiency, depression and smoking are contributed to increased prevalence of this disease. Some studies reported that antiretroviral therapy may also relate to bone diseases in HIV patients.\n\nAim of the study: To assess plasma levels of bone metabolism biomarkers in HIV infected patients before and after ART treatment.\n\nMaterials and methods: Leftover blood samples from advanced clinical monitoring project were used for this study. 156 individuals with HIV infection before and after ART at different stages of treatment (0, 6 and 12 months) were investigated. Plasma level of bone metabolism biomarkers like PTH, phosphate, Vitamin D and Osteocalcin were measured using Cobas 6000 chemistry machine. Data analysis was carried out by means of statistical package for social science version 16.\n\nResults: The mean level of PTH and Osteocalcin increased significantly in HIV infected patients taking ART compared to HIV patients not taking ART (p value<0.05). Viral load was negatively correlated with PTH, Osteocalcin, Vitamin D and Phosphate.\n\nConclusions: As the duration of treatment with ART extended, further increase of the higher rate of bone turnover in HIVinfected patients was observed.
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